The Hyperleptinemia of Obesity—Regulator of Caloric Surpluses
نویسنده
چکیده
New evidence suggests that leptin and other anorexigenic agents reduce appetite by inactivating hypothalamic AMP-activated protein kinase (AMPK), thereby increasing malonyl CoA levels. This preview examines AMP biology and its role in malonyl-CoA generation and attempts to integrate its central actions with its peripheral antilipotoxic actions within the context of leptin physiology in obesity.
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ورودعنوان ژورنال:
- Cell
دوره 117 شماره
صفحات -
تاریخ انتشار 2004